ParkinsonCanadaV1, Main, Exploration, bibRecord, 001551

Abnormal metabolic brain networks in a nonhuman primate model of parkinsonism

Identifieur interne : 001551 ( Main/Exploration ); précédent : 001550; suivant : 001552

Abnormal metabolic brain networks in a nonhuman primate model of parkinsonism

Auteurs : YILONG MA [États-Unis] ; SHUCHUN PENG [États-Unis] ; Phoebe G. Spetsieris [États-Unis] ; Vesna Sossi [Canada] ; David Eidelberg [États-Unis] ; Doris J. Doudet [Canada]

Source :

Journal of cerebral blood flow and metabolism [ 0271-678X ] ; 2012.

RBID : Pascal:12-0202616

Descripteurs français

Pascal (Inist)
- Parkinsonisme, Maladie de Parkinson, Pathologie du système nerveux, Pathologie cérébrovasculaire, Encéphale, Primates, Modèle animal, Glucose, Tomoscintigraphie, Tomographie par émission de positons.
Wicri :
- topic : Glucose.

English descriptors

KwdEn :
- Animal model, Cerebrovascular disease, Emission tomography, Encephalon, Glucose, Nervous system diseases, Parkinson disease, Parkinsonism, Positron emission tomography, Primates.

Abstract

Parkinson's disease (PD) is associated with a characteristic regional metabolic covariance pattern that is modulated by treatment. To determine whether a homologous metabolic pattern is also present in nonhuman primate models of parkinsonism, 11 adult macaque monkeys with parkinsonism secondary to chronic systemic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 12 age-matched healthy animals were scanned with [¹⁸F]fluorodeoxyglucose (FDG) positron emission tomography (PET). A subgroup comprising five parkinsonian and six control animals was used to identify a parkinsonism-related pattern (PRP). For validation, analogous topographies were derived from other subsets of parkinsonian and control animals. The PRP topography was characterized by metabolic increases in putamen/pallidum, thalamus, pons, and sensorimotor cortex, as well as reductions in the posterior parietal-occipital region. Pattern expression was significantly elevated in parkinsonian relative to healthy animals (P< 0.00001). Parkinsonism-related topographies identified in the other derivation sets were very similar, with significant pairwise correlations of region weights (r>0.88; P<0.0001) and subject scores (r>0.74; P<0.01). Moreover, pattern expression in parkinsonian animals correlated with motor ratings (r> 0.71; P< 0.05). Thus, homologous parkinsonism-related metabolic networks are demonstrable in PD patients and in monkeys with experimental parkinsonism. Network quantification may provide a useful biomarker for the evaluation of new therapeutic agents in preclinical models of PD.

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is associated with a characteristic regional metabolic covariance pattern that is modulated by treatment. To determine whether a homologous metabolic pattern is also present in nonhuman primate models of parkinsonism, 11 adult macaque monkeys with parkinsonism secondary to chronic systemic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 12 age-matched healthy animals were scanned with [<sup>18</sup>
F]fluorodeoxyglucose (FDG) positron emission tomography (PET). A subgroup comprising five parkinsonian and six control animals was used to identify a parkinsonism-related pattern (PRP). For validation, analogous topographies were derived from other subsets of parkinsonian and control animals. The PRP topography was characterized by metabolic increases in putamen/pallidum, thalamus, pons, and sensorimotor cortex, as well as reductions in the posterior parietal-occipital region. Pattern expression was significantly elevated in parkinsonian relative to healthy animals (P< 0.00001). Parkinsonism-related topographies identified in the other derivation sets were very similar, with significant pairwise correlations of region weights (r>0.88; P<0.0001) and subject scores (r>0.74; P<0.01). Moreover, pattern expression in parkinsonian animals correlated with motor ratings (r> 0.71; P< 0.05). Thus, homologous parkinsonism-related metabolic networks are demonstrable in PD patients and in monkeys with experimental parkinsonism. Network quantification may provide a useful biomarker for the evaluation of new therapeutic agents in preclinical models of PD.</div>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Abnormal metabolic brain networks in a nonhuman primate model of parkinsonism

Abnormal metabolic brain networks in a nonhuman primate model of parkinsonism

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri